Brasseler’s next generation bioceramic sealer with enhanced handling, versatility and ion release to provide optimal long-term sealing of the entire root canal system.

BUY BC SEALER ION+

COLD & WARM OBTURATION

IMPROVED HANDLING

INCREASED RADIOPACITY

ENHANCED BIOACTIVITY

The next generation of bioactive sealer, brought to you by the leader in bioceramic endodontic materials.

Ion+ Whiteboard: Rev 0 – December 2024

BC Sealer ion+ is a patented, revolutionary, premixed bioceramic sealer based on Akermanite, which is a well-established mineral used in the medical field due to its osteogenic and angiogenic properties. Unlike all other bioceramics, BC Sealer ion+ releases both calcium and magnesium ions for maximum bioactivity.

  • Cold and Warm Techniques
  • Improved Handling
  • Increased Radiopacity
  • Enhanced Bioactivity
    • 2x Tissue Repair
    • Stem Cell Differentiation
    • Micronized Particles
    • Antibacterial Effect
BC Sealer ion+ BC Sealer
Bioceramic components Calcium and magnesium silicate (17%)
Calcium sulfate hemihydrate (5%)
Calcium Oxide (2%)
Potassium sulfate (2%)		 Tricalcium silicate (20-35%)
Dicalcium silicate (5%)
Calcium hydroxide (1-4%)
TOTAL 26% TOTAL 27%
Radiopacifier Zirconium Oxide (40%) Zirconium Oxide (35-45%)
Fillers and thickening components Polyethylene Glycol (32.5%)
Thickening agents (2.5%)		 Propylene Glycol (32.5%)
Thickening agents (2.5%)

BC Sealer ion+ has similar properties compared to traditional BC Sealer.

BC Sealer ion+ BC Sealer ISO 6876: 2012
(Standard Value)
Radiopacity

6.8 ± 0.8 Al

4.8 ± 0.8 Al

> 3 mm Al
Flowability

29.5 ± 2.6 mm

19.9 ± 0.5 mm

> 17 mm
Film Thickness

46.7 ± .01 µm

46.7 ± 0 µm

< 50 µm
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MECHANISM OF ACTION

The structural differences between simple tetrahedral nesosilicates (e.g. C3S) and double tetrahedral sorosilicates (e.g. Akermanite) significantly influence their ion release behavior and subsequent bioactivity. While C3S provides rapid Ca2+ release for immediate effects, Akermanite’s controlled release of both Ca2+ and Mg2+ offers prolonged bioactivity, enhanced structural stability, and multifaceted biological benefits.

XP-3D Shaper

When in contact with water, the Calcium Sylicate crystal releases only Calcium ions into the medium.

XP-3D Shaper

When in contact with water, the Akermanite crystal releases Hydroxyl, Calcium, and Magnesium ions into the medium.

RESULTS

Review the results of BC Sealer ion+ for hDP-SCs and hPDL-SCs.

hPD-SCs

(Human Dental Pulp Stem Cells)

Cell Viability: hDP-SCs

MTT Assay

The results showed that, at 48 and 72 hours, BC Sealer Ion+ maintained high cell viability, similar to the control, indicating good biocompatibility and pro-regenerative potential. Endosequence BC Sealer also showed an increase in viability, but it is still inferior to A in long-term performance.

Cell Migration: hDP-SCs

Scratch Wound-Healing Assay

The cell migration results showed that BC Sealer Ion+ exhibited the greatest reduction in the wound compared to Endosequence BC Sealer, demonstrating faster healing at all time assessed. Endosequence BC Sealer reduced the wound, but at a slower rate.

Cell Differentiation (osteoblastic and odontoblastic)

Bone and dentin formation
Dentin sialophosphoprotein (DSPP): 21 days

DSPP/GAPDH Relative gene expression

These results after 21 days indicate that BC Sealer ion+ enhanced the expression of the gene (DSPP/GAPDH ratio) associated with dentin formation, highlighting its superior performance in promoting dentin regeneration compared to Endosequence BC Sealer.

Formation of extracellular matrix (Cementum)

Cementum protein (CEMP1): 21 days

CEMP1/GAPDH Relative gene expression

These results after 21 days indicate that BC Sealer ion+ enhanced the expression of the gene (CEMP1/GAPDH ratio) associated with cementum formation, highlighting its superior performance in promoting cementum regeneration compared to Endosequence BC Sealer.

Formation of extracellular matrix (Collagen)

Bone Matrix Collagen type 1 (Col1A1): 21 days

DSPP/GAPDH Relative gene expression

These results after 21 days indicate that BC Seale Ion+ enhanced the expression of the gene (Col1A1/GAPDH ratio) associated with collagen type I formation, a key component of the bone extracellular matrix. This highlights its superior performance in promoting cellular matrix development and bone collagen production compared to Endosequence BC Sealer.

Alkaline Phosphatase Activity

(ALP Activity): 21 days

CEMP1/GAPDH Relative gene expression

These results after 21 days indicate that BC Sealer Ion+ enhanced the expression of the gene (ALP/GAPDH ratio) associated with alkaline phosphatase activity, a key marker of early osteogenic differentiation. This highlights its superior performance in promoting bone formation processes compared to Endosequence BC Sealer.

hPDL-SCs

(Human Periodontal Ligament Stem Cells)

Cell Viability: hDP-SCs

MTT Assay

The results showed that, at 48 and 72 hours, BC Sealer Ion+ maintained high cell viability, similar to the control, indicating good biocompatibility and pro-regenerative potential. Endosequence BC Sealer also showed an increase in viability, but it is still inferior to A in long-term performance (p < 0.001).

Cell Migration: hDP-SCs exposed to extracts of different cements

Scratch Wound-Healing Assay

The cell migration results showed that BC Sealer Ion+ exhibited the greatest reduction in the wound compared to Endosequence BC Sealer, demonstrating faster healing at all time assessed. Endosequence BC Sealer reduced the wound, but at a slower rate (p<0.05; p<0.01; p<0.001).

Cell Differentiation (osteoblastic and odontoblastic)

Bone and dentin formation
Dentin sialophosphoprotein (DSPP): 21 days

DSPP/GAPDH Relative gene expression

These results after 21 days indicate that BC Sealer ion+ enhanced the expression of the gene (DSPP/GAPDH ratio) associated with dentin formation, highlighting its superior performance in promoting dentin regeneration compared to Endosequence BC Sealer (p<0.001).

Formation of extracellular matrix (Cementum)

Cementum protein (CEMP1): 21 days

CEMP1/GAPDH Relative gene expression

These results after 21 days indicate that BC Sealer ion+ enhanced the expression of the gene (CEMP1/GAPDH ratio) associated with cementum formation, highlighting its superior performance in promoting cementum regeneration compared to Endosequence BC Sealer (p<0.001).

Formation of extracellular matrix (Collagen)

Bone Matrix Collagen type 1 (Col1A1): 21 days

DSPP/GAPDH Relative gene expression

These results after 21 days indicate that BC Seale Ion+ enhanced the expression of the gene (Col1A1/GAPDH ratio) associated with collagen type I formation, a key component of the bone extracellular matrix. This highlights its superior performance in promoting cellular matrix development and bone collagen production compared to Endosequence BC Sealer (p<0.001).[/et_pb_slide][et_pb_slide heading="Alkaline Phosphatase Activity" image="https://brasselerusadental.com/wp-content/uploads/sites/9/2025/03/[email protected]" _builder_version="4.18.0" _module_preset="default" background_layout="light" global_colors_info="{}" sticky_transition="on"]

(ALP Activity): 21 days

CEMP1/GAPDH Relative gene expression

These results after 21 days indicate that BC Sealer Ion+ enhanced the expression of the gene (ALP/GAPDH ratio) associated with alkaline phosphatase activity, a key marker of early osteogenic differentiation. This highlights its superior performance in promoting bone formation processes compared to Endosequence BC Sealer (p<0.001).

Clinical Cases

Explore real-world clinical cases that demonstrate the power of ion+—because the true test of innovation lies in proven, patient-ready results.

XP-3D Shaper

Initial X-Ray

XP-3D Shaper

Immediate PO

BC Sealer ion+

This clinical case is courtesy of Professor Warley Tavares

XP-3D Shaper

Initial CBCT

XP-3D Shaper

7 Months PO

BC Sealer ion+

This clinical case is courtesy of Professor André Michelotto

What Clinicians are Saying About ION+

I have used Brasseler’s BC Sealer for over 15 years. I recently switched to the new BC Sealer Ion+ because of the improved flow properties, versatility with cold or warm obturation and I was impressed with the additional release of beneficial magnesium ions which should lead to more thorough and rapid healing. It also has excellent radiopacity.

Dr. Alex Fleury

TX

BC Sealer Ion+ offers exceptional practicality with its pre-mixed, ready-to-use formulation, saving valuable time during busy clinical days. Its viscosity allows it to flow into the intricate details of the tooth’s microanatomy, as evidenced by its excellent radiopacity. Moreover, the sealer’s bioactivity promotes a faster healing process, which can be bserved radiographically in shorter periods.

Dr. Joao Barbizam

OR

BC Sealer Ion+ has been sold in Brazil for over 4 years and several well respected prominent research institutions have shown some outstanding results around beneficial ion rlease.

Dr. Gilberto Debelian

Ozlo, NO

Manufactured For
Brasseler U.S.A. Dental, LLC
One Brasseler Blvd
Savannah, GA 31419, U.S.A.

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